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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク De novo transcriptome assembly ： ウィキペディア英語版 De novo transcriptome assembly ''De novo'' transcriptome assembly is the method of creating a transcriptome without the aid of a reference genome. == Introduction == As a result of the development of novel sequencing technologies, the years between 2008 and 2012 saw a large drop in the cost of sequencing. Per megabase and genome, the cost dropped to 1/100,000th and 1/10,000th of the price, respectively.〔(【引用サイトリンク】title=DNA Sequencing Costs: Data from the NHGRI Large-Scale Genome Sequencing Program Available at: www.genome.gov/sequencingcosts )〕 Prior to this, only transcriptomes of organisms that were of broad interest and utility to scientific research were sequenced; however, these newly developed high-throughput sequencing (also called next-generation sequencing) technologies are both cost- and labor- effective, and the range of organisms studied via these methods is expanding. Within the past few years, transcriptomes have been created for chickpea, planarians, ''Parhyale hawaiensis'', as well as the brains of the Nile crocodile, the corn snake, the bearded dragon, and the red-eared slider, to name just a few. Examining non-model organisms can provide novel insights into the mechanisms underlying the "diversity of fascinating morphological innovations" that have enabled the abundance of life on planet Earth. In animals and plants, the "innovations" that cannot be examined in common model organisms include mimicry, mutualism, parasitism, and asexual reproduction. ''De novo'' transcriptome assembly is often the preferred method to studying non-model organisms, since it is cheaper and easier than building a genome, and reference-based methods are not possible without an existing genome. The transcriptomes of these organisms can thus reveal novel proteins and their isoforms that are implicated in such unique biological phenomena. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「De novo transcriptome assembly」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.